AdipoSeeds

AdipoSeeds was established in July 2016, based on the research conducted by Dr. Yumiko Matsubara at Keio University School of Medicine. Leveraging proprietary technologies for the production, preparation, evaluation, and preservation of platelets derived from non-hematopoietic stem cells, we aim to become a "global pioneer in platelet-based regenerative medicine" and solve challenges facing platelet-related medical care worldwide.

Social Impact of Realizing Regenerative Medicine

Regenerative medicine aims to "restore to their original state" the functions of tissues and organs lost due to disease, injury, or aging, utilizing cells and highly biocompatible materials. This differs from conventional medical approaches (such as drug therapy or surgery), which often focus on suppressing symptoms or slowing disease progression.

The realization of regenerative medicine offers the following social impacts:

(1) A True Approach to Extending Healthy Life Expectancy: While average life expectancy continues to rise, a significant gap remains between it and "healthy life expectancy" which is the period during which individuals live independently without becoming bedridden or requiring nursing care. As regenerative medicine is positioned to fundamentally regenerate damaged tissue, its implementation is expected to dramatically improve Quality of Life (QOL) and contribute to maintaining a body capable of active, independent living throughout one's life.
(2) Contribution to Improving Medical Economics: In the realm of social security, there is a need to curb medium - to long-term medical costs by providing curative treatments for diseases that previously required lifelong care. Furthermore, alleviating the psychological and physical burdens on both patients and their caregiving family members is crucial; this helps prevent workforce attrition such as "caregiving-related job resignation" which represents a significant social loss.

While regenerative medicine modalities, such as cell-based products, may appear expensive at first glance, the medical-economic benefits —specifically the reduction of medium- to long-term costs associated with conventional care — are expected to outweigh the initial, temporary increase in treatment expenses. Furthermore, the development of the ecosystem surrounding regenerative medicine is expected to lead to cost reductions.
(3) Establishment of treatments for intractable and rare diseases: There is an expectation that treatments will be established for diseases where, despite medical advancements to date, no means existed to halt their progression. Providing treatment options for these "diseases previously considered untreatable" will generate immense social impact.
(4) Ripple effects on related industries (an ecosystem centered on regenerative medicine): Broad ripple effects are anticipated through integration with machinery, precision equipment, and chemical industries spanning areas such as automated cell culture systems, culture medium development, and cryogenic logistics systems.

As regenerative medicine becomes more widespread, related industries will develop; this, in turn, will lower the cost of providing regenerative medicine, thereby driving even further adoption.

AdipoSeeds' Business Domains

AdipoSeeds aims to become a "global pioneer in platelet-based regenerative medicine" by operating two distinct business lines: (1) Regenerative medicine product development business, which seeks to develop two types of cells, ASCL-PLC and ASCL for medical application; and (2) PRP (Platelet-Rich Plasma) business, focused on PRP therapy, a method of tissue repair utilizing platelets.

Regenerative medicine product
development business

PRP business

Regenerative medicine product development business

AdipoSeeds’ technology is based on the differentiation of ASCL (Adipose-derived Mesenchymal Stem Cell Line) — a mesenchymal stem cell line established through proprietary purification and clonal selection techniques to overcome the limitations of standard ASCs — into ASCL-PLC.

Through years of research on platelets, our founder and CSO, Dr. Yumiko Matsubara, was the first in the world to discover that ASCs, despite being non-hematopoietic cells, possess the potential to differentiate into platelets, and successfully elucidate the underlying mechanism. This discovery demonstrated that platelets could be generated from ASCs using simple culture methods without the introduction of exogenous genes, providing the scientific basis for the low-cost production of safe platelets suitable for medical applications.

We are currently developing ASCL-PLC and ASCL with the aim of obtaining manufacturing and marketing approval under the Pharmaceuticals and Medical Devices Act for their use as allogeneic regenerative medicine products.

Adipose-derived Mesenchymal Stem Cell Line - derived Platelet Like Cells

ASCL-PLC has not only the function of hemostasis but also the higher ability to promote restoration and regeneration of tissue than platelet derived from peripheral blood because ASCL-PLC Inherits the characteristics of mesenchymal system cell.

Indication

Refractory Chronic Skin Ulcer, Platelet Transfusion, Tendon Lesion, etc.

Adipose-derived Mesenchymal Stem Cell Line

ASCL Is homogeneous high Mesenchymal Stem Cell established by using our original method to overcome the drawback of ASC and satisfles the minimal criterla for defining Mesenchymal Stem Cell by The International Society for Cellular Therapy.
ASCL can also be stored long term through freezing and dissolving process.

Indication

Osteoarthritis, Hepatopathy, Immunological Disease, etc.

Pipeline under development

Pipeline

ADS-01
Refractory Chronic Skin Ulcer

ADS-02
Platelet Transfusion

ADS-03
GVHD

Hepatopathy
Osteoarthritis

Tendinopathy

Application in Disaster Situations

Modality

ASCL-PLC

ASCL

ASCL
ASCL-PLC

Basic Research
Applied Research
Pre-Clinical
Clinical Trial
Application for Approval

Related Papers

Hideaki Obara, Kentaro Matsubara, Naoki Fujimura, Yumiko Matsubara, Yukako Ono-Uruga, Masaki Yazawa, Jun Okui, Yasunori Sato, Yuko Kitagawa. Safety and efficacy of long-shelf-life allogeneic adipose-derived　mesenchymal stem cell line-derived platelet-like cells for refractory foot ulcers: A translational preclinical and phase 1/2a study. Regenerative Therapy 30 (2025) 606–615

Akiko Torii, Yuichi Yamada, Yukako Ono-Uruga, Yuiko Sato, Yosuke Kaneko, Satoshi Nakamura, Takuji Iwamoto, Yumiko Matsubara, Morio Matsumoto, Masaya Nakamura, Kazuki Sato & Takeshi Miyamoto. Platelet-like cells differentiated from adipose-derived mesenchymal stem cells inhibit acute inflammation of tendinopathy in rats. Journal of Bone and Mineral Metabolism 2025

Yoshitsugu Fukuda, Yasuo Niki, Munehisa Shinozaki, Yukako Ono-Uruga, Yumiko Mastsubara, Mika Imamura, Masaki Yoda, Masaya Nakamura. Intraarticular injection of adipose-derived mesenchymal stem cell line attenuates pain, synovitis, and cartilage degeneration in monoiodoacetate-induced osteoarthritis rat model. Cell Transplantation Volume 34, 2025

Yuichi Yamada, Akiko Torii, Yukako Uruga, Yuiko Sato, Yumiko Matsubara, Morio Matsumoto, Masaya Nakamura, Kazuki Sato & Takeshi Miyamoto. Platelet like cells differentiated from human adipose derived mesenchymal stem cells promote healing of tendinopathy in rats. Scientific Reports volume 15, Article number: 15015 (2025) Cite this article

Chen K , Obara H, Matsubara Y, Fukuda K, Yagi H, Ono-Uruga Y, Matsubara K, Kitagawa Y. Adipose-derived mesenchymal stromal/stem cell line ameliorates hepatic ischemia/reperfusion injury in rats by inhibiting inflammasome activation. Cell Transplantation. Jan-Dec; 31: 9636897221089629, 2022

Ono-Uruga Y, Ikeda Y, Matsubara Y. Platelet production using adipose-derived mesenchymal stem cells: Mechanistic studies and clinical application. J Thromb Haemost. 2020 Nov 20. doi: 10.1111/jth.15181.

Tozawa K, Ono-Uruga Y, Yazawa M, Mori T, Murata M, Okamoto S, Ikeda Y, Matsubara Y. Megakaryocytes and platelets from novel human adipose-derived mesenchymal stem cell line. Blood. 133 (7): 633-643, 2019

PRP business

PRP (Platelet-Rich Plasma) therapy is a form of regenerative medicine in which PRP, extracted and prepared from the patient's own blood, is administered to an affected area. It is utilized across various fields, including orthopedics (for conditions such as osteoarthritis of the knee and disorders of muscles, tendons, and ligaments), dermatology and plastic surgery (for intractable conditions and aesthetic medicine), and dentistry.

This therapy is garnering attention because the growth factors and cytokines contained in platelets directly stimulate processes such as cell proliferation and collagen synthesis, thereby eliciting the body's natural healing capabilities for damaged tissue. Furthermore, as it uses the patient's own blood (autologous origin), it offers a high level of safety; it requires no surgery and can be performed as an outpatient procedure. Its low risk of side effects also makes it an attractive option for safe, repeated, and continuous use.

However, significant challenges remain regarding the standardization and reproducibility of PRP quality. Platelet counts and functions vary widely among individuals and are influenced by factors such as age, medication, and diet, making it difficult to ensure consistent quality.

To address this, AdipoSeeds has developed a proprietary preparation technology that achieves stable PRP quality by maintaining platelet function, ensuring a high platelet recovery rate, and minimizing contamination by red and white blood cells.

Nevertheless, variations stemming from individual patient differences and physical conditions cannot be eliminated entirely. Therefore, by combining our preparation method with unique evaluation technology that "visualizes" the quality of the prepared PRP, we can utilize the resulting data to help medical institutions verify treatment efficacy and plan repeated administrations. We believe this approach contributes to solving the societal challenge of realizing safe, convenient regenerative medicine which is the fundamental goal of PRP therapy.

Cytokines included in platelets and their functions

PDGF
Platelet-Derived Growth Factor

Proliferation of fibroblast, vascular smooth muscle cell, etc.
Tissue Repair

TGF-β
Transforming Growth Factor-β

Control of cell proliferation and differentiation
Promotion of apoptosis
Control of inflammatory and immunity function

bFGF
basic Fibroblast Growth Factor

Proliferation of mesenchymal stem cell
Protection of nerve cell
Tissue Repair

VEGF
Vascular Endothelial Growth Factor

Proliferation of vascular endothelial cell
Tube formation

EGF
Epidermal Growth Factor

Proliferation of epithelium cell

Application field of PRP therapy as Regenerative Medicine using Platelets

Injury of Intraarticular cartilage and tendon

Wrinkle removing Skin regeneration — Skin regeneration

Key Features of AdipoSeeds’ PRP Preparation Technology

(1) Provision of PRP with preserved platelet functionality: When PRP is administered to a treatment site, the platelets within it become "activated" upon receiving stimuli such as adhesion to tissue collagen via their membrane receptors. This activation triggers the release of growth factors and cytokines, which are crucial for tissue regeneration. High therapeutic efficacy relies on the platelets' ability to adhere to the wound site and subsequently activate via these receptors after administration. Therefore, our service provides PRP in which this essential platelet functionality is preserved.
(2) Preparation possible with a small blood sample: Due to the high recovery rate achieved during preparation, only a small volume of blood is required, thereby minimizing the physical burden on the patient.
(3) Provision of "Super Pure PRP" with minimal contamination from non-platelet components: Numerous clinical reports indicate that lower levels of contaminating leukocytes (white blood cells) in PRP correlate with higher therapeutic efficacy. Furthermore, the presence of erythrocytes (red blood cells) is known to negatively impact PRP's therapeutic effects. AdipoSeeds' technology enables the preparation of PRP with minimal contamination from leukocytes and erythrocytes.
(4) Accumulation of evidence through the "visualization" of post-preparation PRP quality: By utilizing AdipoSeeds' proprietary technology, we can go beyond simply measuring the quantity of growth factors and cytokines in the PRP; we can also evaluate the platelets' functional capacity to release these substances. This data allows us to correlate results with therapeutic outcomes and serves as a valuable reference for planning subsequent treatments.
(5) Platelet function is maintained even after several weeks of storage.: Conventional PRP is difficult to store, so the standard practice was to administer it immediately after preparation; however, AdipoSeeds' technology enables storage for up to several weeks.

AdipoSeeds PRP Adoption Record

It has been adopted by Keio University Hospital,
and details are available on the hospital's website.

Keio University Hospital

If you are interested in the PRP therapy offered by AdipoSeeds,
please contact us via the link below.

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