AdipoSeeds has concluded a collaborative research agreement with Azabu University (Research Director: Professor Masaharu Hisashi, Faculty of Veterinary Medicine) and initiated collaborative research on the production of platelet-like cells derived from adipose tissue in dogs.

 

Thrombocytopenic disorders, including immune-mediated thrombocytopenia, are common in dogs, and platelet transfusions are essential in severe cases. However, in veterinary practice, there are still structural challenges such as short storage time of platelet products and lack of blood transfusion infrastructure, making it difficult to provide platelet products in a stable way.

 

Our mission is to produce platelets from adipose tissue and create a new blood flow. It aims to provide safe and medically applicable platelet products from human adipose tissue that will be discarded after a surgery of liposuction. In the future of a low-birth rate and aging society, we will contribute to solving the challenge of platelet shortage, which will accelerate globally, and create a future where treatment practices involving platelets can be safely offered at a lower cost.

 

We have already established a technology to produce platelet-like cells from human adipose tissue, and we have conducted first-in-human study for the treatment of intractable skin ulcers at Keio University Hospital. In addition, we plan to begin a clinical trial in Japan for intractable  skin ulcers within 2025.

 

In collaboration with Azabu University, we aim to solve the shortage of platelet products in veterinary practice by applying the technique established in humans to dogs, which produces adipose tissue-derived platelet-like cells.

 

With regard to the outline of this collaborative research, an oral presentation will be made on the subject of “Induction of megakaryocyte-like cells from canine adipose-derived mesenchymal stem cells” by Ms. Misaki Matsui, et al. of the Research Laboratory of Small Animal Medicine, Azabu University, at the scientific meeting of the Veterinary Society of Japan held on September 3-6, 2025.

 

Induction of differentiation into megakaryocytes from canine mesenchymal stem cells will be the world’s first unprecedented report and the result is expected to contribute to the development of blood transfusion supply in veterinary medicine in the future.